Which of the following is a classic symptom of acute appendicitis?

The classic symptom of acute appendicitis is pain localized to the right lower quadrant. This symptom arises due to irritation of the peritoneum around the inflamed appendix. As the appendix becomes inflamed, it often presents with visceral pain initially, which may be vague and central. However, as the inflammation progresses, the pain becomes more pronounced and shifts to the right lower quadrant, often becoming sharp and more severe, a phenomenon known as "rebound tenderness."

Patients may also experience other associated symptoms, such as nausea, vomiting, and possibly fever, but the hallmark of appendicitis is indeed the specific localization of pain to the right lower quadrant, reflecting the anatomical position of the appendix. This key symptom helps healthcare professionals in diagnosing acute appendicitis promptly and appropriately.